John,
Once a leaf is flue-cured, it will age very slowly thereafter, since the most active enzyme, and oxidase, is destroyed. For flue-cure varieties, the objective is to lock in the light color, the pH and the sugar.
Among flue-cure varieties, I see dramatic differences in the quality of the flue-cured product. Paris Wrapper and Silk Leaf never developed the crepe-like texture that is easy to get with VA Bright. And they were consistently darker.
Burley starts out with a different chemical composition (compared to flue-cured varieties). I'm not sure what you'd get.
For some Oriental varieties, this works out fairly well. For cigar leaf, for example, flue-curing may leave you with leaf that requires many years to finish. I've never tried it.
I did flue-cure some Xanthi-Yaka 18a. It is alright for a pipe blender, but not nearly as nice as either air-cured Xanthi or the traditional sun-cured Xanthi. The Çelikhan also doesn't do all that well when flue-cured.
Another unanswered question is what happens if you flue-cure a cigar variety, then kiln it.
I think that some of the thick-leaved Hungarian varieties might flue-cure well, but again, I haven't tried it.
Bob