Tobacco needs oxygen to age. The aging process itself is an oxidation process. Just about any packaging or container that you and I can provide will still have sufficient oxygen present for aging to occur. I suspect that those primary oxidative processes are fairly complete after only 3-6 years. Sooner if the leaf has been adequately kilned.
There is also the mystery of tobacco gradually losing volatile compounds. I think, for the most part, it is just an equilibrium process—the volatiles are lost from the tobacco, until the concentration in the ambient space is equal to that remaining in the tobacco. So, "airing" or "resting" the aged tobacco for an hour or a week after finally opening it, dissipates those vapors. What are these "volatiles"? I don't really know. But my 10 year old cigar short scrap has lost its ability to create a room note of "cigar".
Because mold spores are ubiquitous in our environment, moldy tobacco is always the result of user error—storing the tobacco with excess moisture. Your natural tobacco cannot be stored long-term in the squishy (propylene glycol and glycerin softened) condition of commercial tobacco. Store it in low case.
Bob
EDIT: Another user error causing stored tobacco to mold is placing the container in a thermal gradient. This can happen by storing tobacco in a location with an unstable temperature (e.g. the attic), or storing it in a location where one surface of the container is exposed to a different temperature than another. Even if the tobacco begins in low case, the warmer surface will "pump" moisture out of the nearby tobacco, and into cooler tobacco. This can cause tobacco in the warmer portion of the container to fall completely out of case (shatters with the slightest handling), while raising the case of tobacco in the cooler portion of the container to medium or high case, which leads to mold.